Heike Daldrup-Link M.D., Ph.D.

Daldrup-Link, Heike
Position Department / Business Unit
Associate Professor Radiology
Institution Disciplines
Stanford University Nanoparticles
City State / Provence
Stanford CA
Country Website
US link
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Dr. Daldrup-Link develops translational “cellular imaging” techniques for cancer and stem cell imaging applications. Examples of current projects: (i) evaluations of clinically applicable nanoparticles for the diagnosis of tumor-associated inflammatory immune responses, (ii) development of immune cell tracking techniques for monitoring cancer immunotherapies, (iii) in vivo stem cell tracking, (iv) imaging (stem cell) transplant rejection (v) evaluation of "smart", activatable nanoparticles for diagnosing stem cell engraftment outcomes. Dr. Daldrup-Link’s research lab has a strong focus on translational applications. Her lab currently conducts clinical trials on staging malignant lymphomas and sarcomas with iron oxide nanoparticles, based on an IND for “off label” use of the iron supplement ferumoxytol as a cell-specific contrast agent for MR imaging. Dr. Daldrup-Link’s research efforts ultimately aim to combine clinically applicable nanoparticles with whole body imaging techniques in order to create comprehensive, "one-stop" anatomical and functional assessments of specific cell populations in vivo, in patients.

Dr. Daldrup-Link completed her training at the Universities in Muenster and Munich, Germany, including her medical degree (1992), Radiology residency (2000), fellowship in Pediatric Radiology (2003) and PD thesis in MRI Contrast Media Research (2003). From 2003 to 2010, Dr. Daldrup-Link worked as an assistant professor (2003-2006) and associate professor (2006-2010) of Radiology at the University of California, San Francisco (UCSF). She joined the Radiology Department at Stanford University in 2010 as an Associate Professor of Radiology and Director of the Translational Tumor and Stem Cell Imaging lab.

Career Highlights

Dr. Daldrup-Link is a member of the following: Board of Directors of the Society for Pediatric Radiology (SPR); the oncology committee of the SPR, the Children’s Oncology Group (COG); the editorial boards of the journals Radiology, European Radiology, Academic Radiology and Pediatric Radiology; the molecular imaging scientific program committee for the Annual Meeting of the Radiological Society of North America (RSNA) and the World Molecular Imaging Conference (WMIC), and a member of the NIH-NCI Cancer Immunology and Immunotherapy Study Section.

Awards

1997                Caffey Award

2000                Coolidge Award

2002                Stipend for RSNA International Young Academics Seminar

2005                Roentgen Award

2005                UCSF Innovations in Science Award

2006                Radiology Research Alliance Young Investigator Award

2007                Caffey Award

2007                Certificate of appreciation for outstanding contributions to the Journal “European Radiology" as Editorial Board Member

2009                “Berdon Award” from the Society for Pediatric Radiology

2010               Chairperson, Imaging and Radiotherapeutics Subcommittee, AACR

2010-12           Member, Molecular Imaging Committee, Rad Society of North America

2010               Editor's recognition award with special distinction, Radiology

2010 -             Elected Member, Board of Directors of the Society for Pediatric Radiology

2011               Distinguished Reviewer, Journal of Magnetic Resonance Imaging

2011               Editor's recognition award with special distinction, Radiology

2011                Author of the 10th and 17th most cited articles in the Journal of Visualized Experiments, out of 1,100+ articles that were published since the inception of the journal

2011                Research featured on the cover of Clinical Cancer Research


2012                “Berdon Award” from the Society for Pediatric Radiology

2012                Distinguished Investigator Award of the Academy of Radiology Research


Books

Daldrup-Link HE, Gooding C (Co-Editors): “Essentials of Pediatric Radiology”, Cambridge University Press, 2010.

Daldrup-Link HE, Gooding C (Co-Editors): “Kinderradiologie: Bildgebende Verfahren in der Paediatrie” (=German Translation of the book: Essentials of Pediatric Radiology), Hans Huber Verlag (=publisher)

Daldrup-Link HE, Newman B (Co-Editors): “Pearls and Pitfalls in Pediatric Radiology”, Cambridge University Press

 

Important Articles

Selected Publications (out of 110);

Khurana A, Nejadnik H, Gawande R, Lee S, Derugin N, Pisani L, Daldrup-Link HE. Intravenous ferumoxytol allows monitoring migration of bone marrow macrophages into stem cell transplants. Radiology 2012 in press

Henning TD, Gawande R, Khurana A, Tavri S, Mandrussow L, Golovko D, Horvai A, Sennino B, McDonald D, Meier R, Wendland M, Derugin N, Link TM, Daldrup-Link HE: MR Imaging of Ferumoxides labeled Mesenchymal Stem Cells in Cartilage Defects: in vitro and in vivo investigations. Molecular Imaging 11(3):197-209, 2012

Daldrup-Link HE, Golovko D, Ruffell B, Denardo DG, Castaneda R, Ansari C, Rao J, Tikhomirov GA, Wendland MF, Corot C, Coussens L: MR imaging of tumor associated macrophages with clinically applicable iron oxide nanoparticles. Clinical Cancer Research 17(17):5695-704, 2011

Meier R, Golovko D, Tavri S, Henning TD, Knopp C, Piontek G, Rudelius M, Heinrich P, Reinhardt V, Heinrich P, Wels W, Daldrup-Link HE: Depicting adoptive immunotherapy for prostate cancer in an animal model with MR Imaging. Magn Res Med
65(3):756–763, 2011

Nedopil A, Klenk C, Kim C, Golovko D, Li S, Wendland M, Daldrup-Link HE:
MR Signal Characteristics of Viable and Apoptotic Human Mesenchymal Stem Cells in MASI for Treatment of Osteoarthritis. Invest Radiol 45(10):634-40, 2010

Meier R, Henning TD, Boddington S, Tavri S, Arora S, Corot C, Daldrup-Link HE: Breast cancers: MR imaging of folate receptor expression with the folate-specific nanoparticle P1133. Radiology 255(2):527-35, 2010

Golovko D, Henning T, Bauer JS, Settles M, Frenzel T, Mayerhofer A, Rummeny E, Daldrup-Link HE: Accelerated stem cell labeling with ferucarbotran and protamine. Eur Radiol. 20(3): 640-8, 2010

Henning TD, Sutton EJ, Kim A, Golovko D, Horvai A, Ackerman L, Sennino B, McDonald D, Lotz J, Daldrup-Link HE: The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells and implications for MR imaging. Contrast Media Mol Imaging 4(4): 165-173, 2009

Henning T, Saborowski O, Golovko D, Boddington S, Bauer J, Fy Y, Meier R, Pietsch H, Sennino B, Daldrup-Link HE: Cell labeling with the positive MR contrast agent Gadofluorine M. Eur Radiol 17(5):1226-34, 2007

Simon GH, von Vopelius-Feldt J, Fu Y, Schlegel J, Piontek G, Wendland MF, Mei-Hsiu C, Daldrup-Link HE: Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of antigen-induced arthritis: a comparative study between SHU555C, Ferumoxtran-10 and Ferumoxytol. Investigative Radiology 41(1):45-51, 2006

Daldrup-Link HE, Meier R, Rudelius M, Piontek G, Piert M, Metz S, Settles S, Uherek C, Schlegel J, Rummeny EJ: In-vivo Tracking of genetically engineered anti-HER2/neu directed Natural Killer to HER2/neu positive Mammary Tumors with Magnetic Resonance Imaging. Eur Radiol 15(1): 4-13, 2005

Daldrup-Link HE, Rudelius M, Piontek G, Metz S, Bräuer R, Debus G, Corot C, Schlegel J, Link TM, Peschel C, Rummeny EJ, Oostendorp RAJ: Migration of iron oxide labeled human hematopoietic progenitor cells in a xenotransplant model: in vivo monitoring using clinical magnetic resonance imaging equipment. Radiology 234(1): 197-205, 2005

Daldrup-Link HE, Rydland J, Helbich T, Turetschek K, Haraldseth O, Link TM, Brasch RC, Shames D, Rummeny EJ: Quantitative MRI-Estimates of breast tumor microvascular permeabilities to the macromolecular contrast agent Feruglose (Clariscan) correlate with histologic tumor grade: Initial Phase II Multicenter Trial. Radiology 229(3): 885-92, 2003

Rudelius M, Daldrup-Link HE, Heinzmann U, Piontek G, Settles M, Link TM, Schlegel J: Highly efficient paramagnetic cellular labeling by standard transfection protocols. Eur J Nucl Med Mol Imaging 30: 1038-1044, 2003

Daldrup-Link HE, Rudelius M, Oostendorp RAJ, Settles M, Piontek G, Metz S, Heinzmann U, Rummeny EJ, Schlegel J, Link TM: Targeting of Hematopoietic Progenitor Cells with MR Contrast Agents. Radiology 228: 760-767, 2003


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