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NIST: First NanoParticles for Bio Research

by Editor1 last modified March 27, 2008 - 12:14

The National Institute of Standards and Technology (NIST) has issued its first set of nanoscale reference materials for labs studying impact of nanoparticles for biomedical research.

NIST: First NanoParticles for Bio Research

Gold nanoparticles created by NIST and NCI via an electron micrograph at 250,000 times magnification for use as reference standards in biomedical research laboratories.

Three new materials, gold spheres nominally 10, 30 and 60 nanometers in diameter, were developed in cooperation with the National Cancer Institute's Nanotechnology Characterization Laboratory (NCL). Their purpose: To serve as a reference standard in biomedical research labs.

NIST’s ‘Gold 'Nano-Particle' Standard’ Up Close
NIST’s new reference materials are citrate-stabilized nanosized gold particles in a colloidal suspension in water. They were “extensively analyzed” NIST said by their scientists to assess particle size and size distribution by multiple techniques for dry-deposited, aerosol and liquid-borne forms of the material.

The new materials were chemically analyzed for the concentrations of gold, chloride ion, sodium and citrate, as well as pH, electrical conductivity, and zeta potential (a measure of the stability of the colloidal solution). They were also sterilized with gamma radiation and tested for sterility and endotoxins.

Dimensions were measured using six independent methods--including atomic force microscopy (AFM), transmission electron microscopy (TEM), scanning electron microscopy (SEM), differential mobility analysis (DMA), dynamic light scattering (DLS), and small-angle X-ray scattering (SAXS). At the nanoscale in particular, different measurement techniques can and will produce different types of values for the same particles.

NIST details of measurement procedures and data with each ordered sample.