Chenzhong Li Ph.D.

Li, Chenzhong
Position Department / Business Unit
Assistant Professor Biomedical Engineering Department
Institution Disciplines
Florida International University Chemistry Engineering Nanomaterials Nanomedicine Nanostructures Nanoparticles
City State / Provence
Miami Florida
Country Website
US link
305 348 6954

Dr. Chenzhong Li's research interests interface with biomedical engineering, nanobiotechnology, electrochemistry, BioMEMS, biochemistry, nanomedicine, surface science, and materials science. The work done here looks ahead to the next generation of nanoelectrical components such as protein nanowires, DNA transistors as well as end use electronic devices such as Lab-on-Chip, biosensors and enzymatic biofuel cells.

Research Interests:
One major research interest is the development of biosensors. Biosensor systems are urgently needed for medicine and for security – for biomedical diagnoses, bio/pharma research, genetic screening, drug screening, cancer cell detection, bio-defense, and environmental protection. The integration of nanotechnology with biology, advanced MEMS technology and electrochemistry opens the possibility to increase the sensitivity and miniaturize the biosensor devices. These systems will be portable or implantable, low cost, easy to use and capable of simultaneously detecting and identifying multiple biomolecular components in real time. This work is mainly broken down into three electrochemical biosensor technologies.

The biofuel cell project is devoted to the development of an implantable, miniature, long-lived power source. This fuel cell would be powered by the coupling of glucose oxidation and the reduction of molecular oxygen to water. This solves a major challenge in the development of future medical devices: namely finding a semi-permanent power source for miniature systems implanted in the human body. Enzymatic biofuel cells show promise as a solution to this problem because of their self-supplementation of biofuel resources and biocatalysts, such as glucose, glucose oxidase, NADH, and the hemoproteins that are present in the human body. As an added benefit, the only byproducts of a biofuel cell are carbon dioxide and water.

The nanoelectronic, biosensors, and biofuel cell projects will lead to novel and powerful tools for fundamental biological research, ultra-high throughput drug screening and medical diagnostics applications. Nanomaterial integrated biosensor devices and implantable enzymatic biofuel cells will provide unparalleled sensitivity and specificity for the real-time analysis of biological components from gene and drug screening to cancer cell or toxin detection, as well as an enzyme-based power source for biomedical device operations.


Dr. Li received his Ph.D. from Kumamoto University in Japan in 2000.

Career Highlights

Dr. Li served one year as a post-doctoral research associate at the University of British Columbia and two years as a professional research associate at the University of Saskatchewan and Adnavance Technologies, Inc. He worked at Nanobiotechnology/Biosensor Group of the Biotechnology Research Institute, Canada National Research Council as an Assistant Research Officer till 2004. Dr. Li is an expert in nanobiotechnology and electrochemistry, specifically in the development of bioelectronics including biosensors and biofuel cells. Dr. Li’s research interests also include nanomaterial process, BioMEMS, nanotoxicity measurements and electron transfer study of various biomolecules.

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