Ravi Radhakrishnan Ph.D.

Radhakrishnan, Ravi
Position Department / Business Unit
Assistant Professor of Bioengineering
Institution Disciplines
University of Pennsylvania Engineering Nanobiology
City State / Provence
Pennsylvania
Country Website
USA link
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My research interests lie in the interface of chemical physics and molecular biology and is currently focussed on biophysical and biochemical aspects of carcinogenesis, therapeutic inhibition of signaling enzymes, RNA catalysis, membrane phenomena, and resistance mechanisms in antibiotics.

With the objective of designing drugs rationally and customized to specfic patients, we investigate biochemical phenomena at various length and timescales from electronic structure to signaling pathways by employing tools from computational biology, statistical mechanics, quantum mechanics, and high performance computing.

Education

B. Tech, 1995, Indian Institute of Technology, Madras; Ph.D., 2001, Cornell University

Important Articles

R. Radhakrishnan and T. Schlick, "Biomolecular Free Energy Profiles by a Shooting/Umbrella Sampling Protocol (BOLAS)", 2004, J. Chem. Phys., 121, 2436.

R. Radhakrishnan and T. Schlick, "Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta’s closing", 2004, Proc. Nat. Acad. Sci., 101, 5970.

R. Radhakrishnan, B. L. Trout, "Nucleation of crystalline phases of water under homogeneous and inhomogeneous environments", 2003, Phys. Rev. Lett., 90, 158301

C. Lo, C. A. Giurumescu, R. Radhakrishnan, B. L. Trout, "Methanol coupling in the zeolite chabazite studied via first-principles molecular dynamics", 2004 Mol. Phys., 102, 281.

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