Yong Gao Ph.D.

Gao, Yong
Position Department / Business Unit
Associate Professor
Institution Disciplines
Southern Illinois University Nanomaterials Nanobiology
City State / Provence
Illinois
Country Website
United States link
Fax
(618)453-6408
Magnetic Organic Nanomaterials and Biomaterials

            Our research efforts have been focusing on design, synthesis and application of magnetic nanomaterials and biomaterials.  We are particularly interested in the use of magnetic nanoparticles for nano-catalysis and bio-imaging.

Magnetic nanoparticle-supported chemical, biological and biomimetic catalyses.  Recycling of homogeneous metal catalysts is a great challenge in industrial processes.  Our group has recently examined the employment of magnetic nanoparticles as novel soluble matrices for supporting a number of metal-mediated organic reactions.  Under an external magnetic field, a soluble catalyst immobilized on the surface of a magnetic nano-matrix can be magnetically concentrated and recovered for repeated uses.  Magnetic nanometer-sized particles were also investigated as an orthogonal matrix of solid-phase resins for chromatography-free work-ups of three-phase reactions.

In addition, our group is also interested in magnetic nanoparticle-supported enzymatic and biomimetic catalyses.  Some of the immobilized bio-catalysts were found to exhibit tunable catalytic activity and selectivity‑‑dependent on the structure of their nano-hosts.

Magnetic nanoparticles as MRI contrast agents for bio-imaging and magnetic modulators for tumor hyperthermia therapies.  Our group has constructed a group of composites of maghemite nanoparticles and polymers/dendrimers.  Maghemite nanoparticles have been approved by the FDA as magnetic resonance imaging (MRI) contrast agents.  Functionalization of magnetic nanoparticles with polymers (dendrimers) will allow us to systematically adjust magnetic relaxivities as well as physiological properties of our nanomaterials for tissue/cell-specific magnetic bio-imaging.


Students and postdoctoral fellows in our group will have an opportunity to be exposed to multidisciplinary research techniques used in organic synthesis, nanomaterials fabrication, and molecular biology.  For example, TEM/SEM, NMR, SQUID, XPS, HPLC, GC, CE, PCR, cell/tissue culture, and small animal experiments were routinely carried out in our laboratory.

Education

B.Sc. Wuhan University, China, 1990; Ph.D. University of Alberta, Canada, 1998

By this Researcher

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