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Uday B. Kompella Ph.D.

At the professional level, Dr. Kompella lectures in the area of biopharmaceutics and pharmacokinetics (Pharmaceutical Sciences I, II, and III). At the graduate level he lectures on drug delivery and transport phenomena (Novel Drug Delivery Systems; Advanced Pharmaceutics; Selected Topics in Ocular Drug Delivery; and Selected Topics in Respiratory Drug Delivery).

Dr. Kompella’s laboratory conducts research on various drug delivery systems including implants, nanoparticles, microparticles, liposomes, and in situ-forming gels. Using these delivery systems and new therapeutic agents, Dr. Kompella's laboratory is developing novel approaches for treating diabetic complications and cancers. The drugs of interest include small molecules as well as macromolecules.

Education

PhD (Pharm. Sci.) - University of Southern California, Los Angeles, USA, M.Pharm (Pharm. Eng.) - Jadavpur University, Calcutta, India, B.Pharm (Hons) - Birla Institute of Technology and Science, Pilani, India.

Awards

2005 Fellow, American Association of Pharmaceutical Scientists. Recognition as a distinguished contributor and acknowledged leader in the advancement of pharmaceutical sciences.

2005 Recognition Award, Regulatory Sciences Section, American Association of Pharmaceutical Scientists

2003 Distinguished Teaching Award, University of Nebraska Medical Center, Omaha

2002 Award of Appreciation by Graduate Students - In recognition of contributions and support as a faculty advisor. XXXIV Annual Pharmaceutics Graduate Research Meeting (June 13-15, 2002). Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE.

1997-98 Alumni Undergraduate Teaching Excellence Award, Auburn University

1997 Recipient of AAPS new investigator grant in pharmaceutics, drug delivery and pharmaceutical technology for 1997. Sponsored by Pfizer Central Research

1997 Recognition Award. American Association of Indian Pharmaceutical Scientists

1996 Who's Who in Science and Engineering, The Marquis Who's Who Publication Board.

1995 Full member, Sigma Xi, The Scientific Research Society

1994 Outstanding Achievement, Office of International Students, University of Southern California, Los Angeles, CA

1993 Student Assistantship from Genentech, Inc. to attend Western Regional AAPS meeting held at San Francisco, CA

1992 Outstanding paper in pharmacokinetics, pharmacodynamics, drug metabolism, and clinical sciences (PPDM & CS) section of AAPS meeting held at San Antonio, sponsored by Eli Lilly & Co.

1992 Best poster award in the graduate student research forum (GSRF) at University of Southern California, sponsored by Doheney Eye Institute, Los Angeles, CA.

1987-89 Fellowship from University Grants Commission, New Delhi, India

1983-87 National Merit Scholarship, India

Books

Nanoparticle Technology for Drug Delivery; Informa (2006)

Important Articles

1. Raghava, S., Hammond, M., and Kompella, U.B. Periocular routes for retinal drug delivery. Exp. Opinion Drug Del. 1:99-114 (2004).
2. Ayalasomayajula, S.P., and Kompella, U.B. Retinal delivery of celecoxib is several-fold higher following subconjunctival administration compared to systemic administration. Pharm. Res. 21(10):1797-1804 (2004).
3. Sundaram, S., Bontha, S.S., and Kompella, U.B. Respiratory delivery of deslorelin, a peptide drug. Am. Pharm. Rev. 7(5):130-139 (2004).
4. Bandi, N., Wei, W., Roberts, C.B., Kotra, L.P., and Kompella, U.B. Preparation of budesonide- and indomethacin- hydroxypropyl-β-cyclodextrin (HPβCD) complexes using an organic-solvent-free, single-step supercritical fluid process. Eur. J. Pharm. Sci. 23(2):159-168 (2004).
5. Ayalasomayajula, S.P., Amrite, A., and Kompella, U.B. Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin-E2 secretion from diabetic rat retinas. Eur. J. Pharmacol. 498:275-278 (2004).
6. Koushik, K., Dhanda, D.S., Cheruvu, N.P.S., and Kompella, U.B. Pulmonary delivery of deslorelin: Large porous PLGA particles and HPβCD complexes. Pharm. Res. 21(7):1119-1126 (2004).
7. Koushik, K. and Kompella, U.B. Transport of deslorelin, an LHRH agonist, is vectorial and exhibits regional variation in excised bovine nasal tissue. J. Pharm. Pharmacol. 56(7):861-868 (2004).
8. Amrite, A.A., Cheruvu, N.P.S., Sundaram, S., Aravalli, R.N., Cheng, P-W, Kompella, U.B. Lung Gene Therapy: Clinical and Regulatory Issues. Clin. Res. Reg. Affairs 21:1-28 (2004).
9. Koushik, K., Bandi, N., and Kompella, U.B. Evidence for LHRH-receptor expression in human airway epithelial (Calu-3) cells and its role in the transport of an LHRH agonist. Pharm. Res. 21:1034-1046 (2004).
10. Sunkara, G., Ayalasomayajula, S.P., Cheruku, R.S., Vennerstrom, J.L., DeRuiter, J., and Kompella, U.B. Systemic and ocular pharmacokinetics of N-4-benzoylaminophenylsulfonylglycine (BAPSG), a novel aldose reductase inhibitor. J. Pharm. Pharmacol. 56:351-358 (2004).
11. Koushik, K. and Kompella, U.B. Preparation of large porous deslorelin-PLGA microparticles with reduced residual solvent and cellular uptake using a supercritical CO2 process. Pharm Res. 21:524-535 (2004).
12. Koushik, K. and Kompella, U.B. Particle and device engineering for inhalation drug delivery. Drug Del. Technol. 4:40-50 (2004).

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