R. Lane Smith Ph.D.
Director, Biologic Research, Orthopedic Biomechanics Section, Stanford University. His group is interested in the molecular and cell biology underlying bone and cartilage metabolism in health and disease. Normal daily activities are linked to the ability of the articular cartilage to withstand normal joint forces that may reach 5-7 times body weight and bone homeostasis depends on daily mechanical loading histories. The phenotypic stability of cartilage and bone depends on a complex interplay between stimuli influencing cell metabolism, physical forces, cytokines, hormones and growth factors, and the genetic expression determining the material properties of the tissue. Dr. Smith is Director, Biologic Research, Orthopedic Biomechanics Section at Stanford University. His lab applies modern biochemical techniques to analyze:1. Mechanisms of cartilage degradation in inflammation and sepsis; 2. Stimulation of cartilage growth and repair by growth factors and hormones in serum-free culture; 3. Effects of adherence and deposition of glycocalyx on bacterial resistance to antibiotic treatment; 4. Effects of mechanical stresses and strains on cartilage and bone cell gene expression and matrix syntheses; 5. Analysis of metal particles on bone resorption and prosthetic loosening in total joint arthroplasty. The experimental techniques include development of primary cultures of human chondrocytes, quantification of proteoglycan and collagen synthesis and degradation, zymogen and kinetic analysis of neutral metalloproteinases, western analysis of protein expression, northern and slot blot analysis of mRNA levels and cloning of connective tissue and bacterial genes. EducationPh.D., University of Texas at Austin, 1971Important ArticlesNanoscale Technology in Biological Systems; The effects of titanium and polymethylmethacrylate particles on osteoblast phenotypic stability, 2006; Comparison of VEGF-producing cells in periprosthetic osteolysis, 2006; Osteoarthritis: current treatment and future prospects for surgical, medical, and biologic intervention, 2004; The mechanobiology of articular cartilage development and degeneration, 2004; Expression of nitric oxide, peroxynitrite, and apoptosis in loose total hip replacements, 2003. |
By this Researcher
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Leburton, Jean-PierreDr. Leburton is the Gregory E. Stillman Professor of Electrical and Computer Engineering at the University of Illinois and a full-time faculty member in the Computational Electronics group in the Beckman Institute.
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