Willy Wriggers Ph.D.
3D Structure and Dynamics of Sub-Cellular Biological Machines; Fast Fourier-Accelerated Correlation Techniques for Structural Biology; Modeling; Electron Microscopy and Imaging; Physics-Based Deformable Models; Haptic Rendering; Molecular Graphics
The main focus of our research is the modeling and 3D structure determination of large sub-cellular biological machines. Our program at the University of Texas Health Science Center at Houston comprises the Laboratory for Structural Bioinformatics at the School of Health Information Sciences, and the Laboratory for Molecular Imaging at the Institute of Molecular Medicine for the Prevention of Human Diseases.
Our inter-disciplinary research team includes doctoral level personnel and students trained in mathematics, biophysics, biochemistry, and computer sciences. Using modern information processing techniques, in concert with physics-based simulation methods, we combine structural data of biological machines from a variety of biophysical sources. In particular, we investigate the architecture, dynamics, and function of large-scale macromolecular assemblies with low-resolution density data from electron microscopy. Our research is currently supported by grants from NIH (1R01GM62968), Human Frontier Science Program (RGP0026/2003), and Alfred P. Sloan Foundation (BR-4297).
EducationVordiplom Physics (U Regensburg) 1991; M.S. Physics (U Illinois Urbana Champaign) 1994; Ph.D. Physics (U Illinois Urbana Champaign) 1998
1991-1994 Predoctoral Fellowship, Friedrich Ebert Foundation, Germany.
1992-1993 Study Abroad Fellowship, German Academic Exchange Service (DAAD), Germany.
1998-1999 Postdoctoral Fellowship, La Jolla Interfaces in Science Program, sponsored by the Burroughs Wellcome Fund.
2001 Journal of Structural Biology, Paper of the Year Award for JSB 125:185-195.
2003-2005 Alfred P. Sloan Fellowship in Computational and Evolutionary Molecular Biology.
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