Polymer Nanoparticles for Gene Delivery: Synthesis and Processing

Authors

Kam W. Leong Department of Biomedical Engineering, Johns Hopkins University School of Medicine

Publication Date

4/13/04

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Abstract

Gene therapy, a therapeutic modality designed to introduce an extraneous gene into the patient's cells to produce a specific protein, potentially can treat a variety of inherited and acquired diseases. Gene medicines are composed of a gene expression vector that encodes a therapeutic protein and a gene delivery system that delivers the gene to the desired tissue and subcellular compartments. The specific and efficient delivery of DNA to the diseased sites and to the nuclei of particular cell populations is the key for successful gene therapy. Gene delivery system plays a central role in fulfilling this mission.

Excerpted From:

Dekker Encyclopedia of Nanoscience and Nanotechnology - 6 Volume Set

Dekker Encyclopedia of Nanoscience and Nanotechnology - 6 Volume Set
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