Antibodies and Other Ligand-Receptor Systems with Infinite Binding Affinity


Claude F. Meares Department of Chemistry, University of California--Davis

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Biological molecules such as antibodies show exquisite specificity in binding to target molecules. This binding is naturally reversible, and the stability of the antibody–target complex is often a matter of concern because experiments can be compromised if it dissociates or exchanges with other molecules. Here we describe the current state of molecular technology for making specific complexes irreversible, so that target specificity is preserved while dissociation is effectively prevented. The emphasis is on antibody applications, but the same concepts apply to other binding systems.