NAPPA Microarrays and Mass Spectrometry. New Trends and Challanges
There has been a marked increase in the use of Mass Spectrometry as Label Free technology to probe NAPPA (Nucleic Acid Programmable Protein Array) microarrays to map proteins and their interactions with various other molecules especially in the area of cancer biology and cell cycle progression.
This booklet focuses on the utilization NAPPA microarrays and highlights its technical challenges and potentialities. The researchers focus on a wide range of applications in basic sciences and in the clinics. NAPPA microarrays and mass spectrometry (MS) represent an innovative and versatile approach to study protein structure abundance and function at an unprecedented scale and resolution. The complex nature of the proteome and the critical role of immobilized protein orientation must be taken into account to maximize the effectiveness of NAPPA microarrays.
Authors of NAPPA Microarrays and Mass Spectrometry. New Trends and Challenges
Rosanna Spera, PhD. postdoctoral research associate in physics/biophysics at the NanoWorld Institute, University of Genoa, Genoa, Italy;
Claudio Nicolini, PhD. Director of the Nanoworld Institute of the University of Genoa